Estrogen dominance? I have a friend with an enlarged thyroid, nodules, hair loss, fatigue, loss of interest in life, and she is very estrogen dominant. Her thyroid levels came back within normal ranges and tested negative for Hashimoto’s. She is searching for answers and is very frustrated. She is 40 years old and a mother of 3 boys. Does anyone know about estrogen dominance and what causes it? How can it be treated? Is it likely that she has a thyroid problem?