Many people are claiming that ceruloplasmin BINDS iron

Question

There is a lot of contradictory information floating around here about the iron issue and I think things need to be cleared up. Many people are claiming that ceruloplasmin BINDS iron (similar to copper). When I have asked for the formula to figure out how much iron is bound to ceruloplasmin I am usually ignored. One person responded to my question (can’t remember her name now) saying that ceruloplasmin does NOT bind iron, it only converts it from one form to another. And she backed this claim up with links to studies.

So if ceruloplasmin truly binds iron, what is the formula for determining the amount of bound iron?

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Becky 3 years 21 Answers 395 views 0

Answers ( 21 )

  1. I thought it bound copper.

  2. I can't wait to hear.

  3. Hey, yes that was me. The link I posted said Cp converted iron to the form that allows it to bind, and be metabolized. Without Cp it would just stay in its storage form.

  4. I missed this convo! Roxanne Ardary can you share that link with me again??

  5. Ceruloplasmin is an enzyme (EC 1.16.3.1) synthesized in the liver containing 6 atoms of copper in its structure.[5] Ceruloplasmin carries more than 95% of the total copper in healthy human plasma.[6] The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state.[7] https://en.wikipedia.org/wiki/Ceruloplasmin

  6. Thank you!

  7. The link, please?!

  8. And this was what the transferrin does:

    When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell (e.g., to erythroid precursors in the bone marrow), it binds to it and, as a consequence, is transported into the cell in a vesicle by receptor-mediated endocytosis. The pH of the vesicle is reduced by hydrogen ion pumps (H+
    ATPases) to about 5.5, causing transferrin to release its iron ions. The receptor (with its ligand, transferrin, bound) is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form (Fe3+
    ).https://en.wikipedia.org/wiki/Transferrin

  9. So what does all of this have to do with my continually low ferritin levels and what can I do to fix them???

  10. Great question!

  11. Becky Evans Morley has written a lot about all the research he is uncovering about iron… he wrote an end of the year missive with some new info he had uncovered. Just a suggestion, but perhaps it would be good to look at the files and see his summaries about iron and see what he says. I do know it all comes down to increasing Cp.

  12. I completely get what he's saying (most of the time). And I love love LOVE reading his replies. They make sense to me. I think it's just one of those things… Some people can read his comments and get what he's saying, and others have a hard time understanding the way he writes. You'll get it eventually I'm sure. Just keep reading and someday it'll click for you 🙂

  13. So Brandi Horst since you understand everything please answer Becky Evans questions.

  14. And if you don't mind..please.provide links..:)

  15. "Transferrin, the major iron-transporting protein in plasma,
    transports iron from sites of storage, such as the liver, to tissues
    using iron. The ferroxidase ceruloplasmin (Cp), which is produced
    by the liver and secreted into the plasma, also plays an
    important role in the movement of iron. By oxidizing the ferrous
    [Fe (II)] form of iron to the ferric [Fe (III)] form, Cp promotes
    iron loading onto transferrin, which only binds the ferric form of
    the metal (Osaki et al., 1966). In addition, Cp is an effective
    antioxidant, because of its ability to oxidize highly toxic ferrous
    iron to the relatively nontoxic ferric form and thus help prevent
    oxidative damage to proteins, lipids, and DNA" –much more about Cp in this article: http://www.jneurosci.org/content/22/15/6578.full.pdf

  16. As a new member I find a lot of the information confusing, requiring individuals to really research at a quite advanced level to understand all the various info, and then this info can be repeated as an absolute.

  17. Im sure you already found this link but I'm posting it anyway. Of course, I don't understand it, so it may not even be what you're looking for
    http://www.jneurosci.org/content/22/15/6578.full.pdf

  18. Ref ranges for iron levels vary widely and can be very confusing/misleading. I am in the UK and a recent ferritin test came back at 165 with a ref range of 20 – 350. Morley says anything over 50 shows overload. I researched ref ranges and discovered info from a UK(NHS) & US web link that stated differences for men and women…. which still took me over "the norm"…. but my UK GP thinks everything is normal because the lab did not give the diff ranges. I will have the HTMA test done via Morley because the NHS medics haven't a clue judging by this shambles of a test and results. No wonder our stress levels are adding to the problem of mineral imbalances and iron and copper issues!!

  19. Becky Evans
    Cp does NOT bind Iron. It ENABLES Iron to be:
    o absorbed in the gut
    o to bind w/ Transferrin…
    o to be loaded into Ferritin….
    o to enable Red Blood Cells to be made
    o and to ensure proper Iron mobilization…
    And THAT'S ^^^^ only what it does to ensure proper Iron metabolism. There are hundreds of other jobs it does that are JUST as important…

    Hope that helps the cause.

    Cheers!

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